Abstract: MATH/CHEM/COMP 2002, Dubrovnik, June 24-29, 2002
The Exception of three Component a-Additions of cations and Anions onto the Isocyanides
Ivar Ugi1, Duanka Janezic2, and Milan Hodoscek2
1 Institute of Organic Chemistry and Biochemistry, Technical University of München, Lichtenbergstr. 4, D-85747 Garching, Germany
2 National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia
The isocyanides are the only chemical compounds whose functional group has a divalent carbon atom CII. In the usual organic chemistry the majority of chemical reactions convert one or two educts into their products, and only rather few multicomponent reactions (MCRs) convert three or four educts into the products. In the chemistry of the isocyanides now the majority of products is formed by MCRs of three to nine educts whereas less isocyanide reactions of one or two educts participate.
It is known that in all chemical reactions one or two educts participate and the only known exception is the solidphase chemistry of three components.
It was now found by the quantum chemical methodology that the four component reaction (U-4CR) of amines, aldehydes, carboxylic acids and isocyanides have a prefinal step which proceeds by the three component reactions as the a-addition of a cations and an anions onto the isocyanides.